12/7/2023 0 Comments Consensus dna![]() Importantly, these studies also revealed that most cognitive disorders are complex and phenotypically and genetically heterogeneous ( Sebat et al., 2007 Tsankova et al., 2007 Voineagu et al., 2011 Weyn-Vanhentenryck et al., 2014), thus creating challenges for studying these disorders. Research on cognitive disorders such as Alzheimer's disease (AD Bullido et al., 1998), intellectual disability (ID Kaufman et al., 2010), autism spectrum disorder (ASD Bailey et al., 1996 Voineagu et al., 2011 Berg and Geschwind, 2012 Ecker et al., 2012), schizophrenia (SZ Andreasen, 1995), circadian rhythm and bipolar disorder (BD Akula et al., 2014, 2016 Takahashi, 2015), Parkinson's disease (PD Polymeropoulos, 2000), and several syndromes or disorders associated with ID or cognitive impairment (SY Greydanus and Pratt, 2005) has thus already identified several candidate genes involved in cognition. For example, causative mutations point to the genes that should in their wild-type variants be important for providing for healthy cognitive abilities. However, the actual molecular mechanisms that underlie these morphological changes are still not well understood.Ĭandidate genes that are involved in the molecular mechanisms of cognition can be identified through biomedical studies on cognitive disorders. In humans, cognitive processes such as use of language, social behavior, and decision-making have been attributed to the frontal lobe ( Duncan et al., 1996 Chayer and Freedman, 2001). Their central role in the network suggests them as excellent new candidates for playing an essential role in the regulatory network of the human frontal lobe, which should be investigated in future studies.īroadly defined, cognition refers to the biological mechanisms through which animals perceive, learn and memorize information from the environment and decide to act upon them ( Shettleworth, 2009). Interestingly, several hubs of the consensus network encode for GRFs that have not yet been associated with brain functions. Within this network, we detected a strong central module that is enriched for 166 GRFs known to be involved in brain development and/or cognitive disorders. This consensus network revealed robust GRF interactions that are conserved across the frontal lobes of different healthy human individuals. To instead focus on the most confident information from these 10 networks we developed a method for integrating such independently derived networks into a consensus network. We observed a high level of variability among these 10 independently derived networks, pointing out that relying on results from a single study can only provide limited biological insights. Using genome wide human frontal lobe expression data from 10 independent data sets, we first derived 10 individual coexpression networks for all GRFs including their potential target genes. Because many of these genes are gene regulatory factors (GRFs) we aimed to provide insights into the gene regulatory networks active in the human frontal lobe. One approach for analyzing the genetic networks involved in cognitive functions is to study the coexpression networks of genes with known importance for proper cognitive functions, such as genes that have been associated with cognitive disorders like intellectual disability (ID) or autism spectrum disorders (ASD). ![]() Not much is known yet about the molecular basis of cognitive abilities, but it seems clear that cognitive abilities are determined by the interplay of many genes. 5Institute for Theoretical Chemistry, University of Vienna, Vienna, AustriaĬognitive abilities, such as memory, learning, language, problem solving, and planning, involve the frontal lobe and other brain areas.4Department of Mathematics and Computer Sciences, University of Southern Denmark, Odense, Denmark.3Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.2Paul-Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany.1Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University Leipzig, Leipzig, Germany.Stefano Berto 1,2,3 * Alvaro Perdomo-Sabogal 1 Daniel Gerighausen 1 Jing Qin 4,5 Katja Nowick 1,2 *
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12/7/2023 0 Comments Shower door sweep t typeTypes of Shower Door Sweeps from pFOkUS: 1. These come in pre-taped and untaped versions and you will need a tape to stick the untaped ones to the door.You can trim it using scissors if you find the length of the fin a bit extra. Push the sweep to the edge of the door.Select a frameless shower door sweep according to the bottom length of your door.Measure the length of your shower door.To install the frameless shower door sweeps, follow the steps given below: Here we have mentioned the installing instructions below. If you are looking for a frameless shower door sweep replacement, you need to first measure the length of your door and pick your sweep according to your door type. You can easily install our sweeps at the bottom of your door as they are made with a latch-on technology. These come with drip rails that help to prevent the leaking water outside the door and instead, redirecting it towards the drain. These are used for frameless shower doors. Shower door sweeps help in covering the gap between your shower door and the ground. Our frameless shower door sweeps are very useful in keeping your showers dry. ![]() ![]() It is quite convenient to push them on the bottom of the shower door. The sweeps have a strong grip and can prevent leaks easily. The sweeps are manufactured from a clear polycarbonate material, which gives them an ideal clarity. They change the direction of the leaking water towards the shower drain. Information on Shower Door Sweeps from pFOkUS:įrameless shower door sweeps retain the water inside the shower and prevent it from leaking outside. So, stop looking for a shower door sweep Amazon or s hower door sweep home depot, or in any other ecommerce portal as you will end up paying more. Their product quality is so good that even D’Sapone – one of the leading glass, tile and grout restoration companies recommends their products for their services. The quality of their products is A-one as they manufacture them after years of research in the laboratories and personal experiences. Not only shower door enclosures, you can find several other products including framed and frameless shower door seals, framed shower door sweeps, shower door thresholds, and shower door sweep replacement parts. PFOkUS is one of the leading shower door enclosures manufacturing companies in the US. Wouldn’t it be better if you purchased your shower door enclosures directly from a wholesaler and manufacturer? Shower Door Sweeps pFOkUS: This amount is inclusive of taxes of the manufacturing company and these ecommerce sites as well. ![]() For example, if a shower door sweep costs around $25, you can find the same at $35 at such portals. You end up paying nearly double the cost price of these products. They then add their own profit margins and taxes to these products to sell them at their portal. Many ecommerce portals avail these products from various retailers, whole-salers and manufacturers. But did you ever cross check the rates at which these products are being sold there? Shower door sweep home depot and shower door sweep lowe’s are definitely high quality products available online easily, but you can also find other economical products at better rates. People buy shower door seals, sweeps or such other glass door enclosures from popular online ecommerce portals like Home depot, Amazon, Walmart or Lowe’s. Common Solutions for Door Leakage Replacement: But, you can check and compare the products available in other websites also. Shower door sweep home depot is a common solution that comes to your mind when you want to fix your leakage. but, this purpose is not solved when the glass doors start leaking. ![]() The basic purpose of installing a shower door is to prevent water splashes to wet your entire bathroom. Shower door leakage is a common problem faced by many of you. 12/7/2023 0 Comments Speedfan not installed(BTW) i couldnt find the best category for this question, sorry. ![]() After reading and using the program a few times, I really enjoyed it. That's pretty much a basic setup, you can also setup the fans to run independent of each other or change the "fan delta value" so they spin up slower if you like. Note: High voltage forced air systems with fans and proprietary systems with fans are not compatible with Nest thermostats. I installed Corsair Link quite a while ago but Im not impressed by it, at least by the lack of options. When finished configuring everything place a shortcut to Speedfan in your startup folder to make it run when the computer is started. Don't forget to check the "automatic speed control" box in Speedfans main window as well. Warning temp will show a little flame icon next to the sensor readout in the main window, as well as triggering all fans to run at 100%, as soon as the warning temp is reached. Experiment with the desired temp until you find the optimum setting. It will not work if this is connected to the light portion of the ceiling fan. As soon as a load is put on the cpu both the chipset fan and cpu fan spin up to the maximum speed set under the speeds tab, then fall back to minimum speed when the cpu is idle again. This Lutron fan control is only for the fan motor only. Highlight Clear System Event Log and press the Enter key. Highlight System Event Log and press the Enter key. When I say, 'Full control', I dont mean that you can just control all your fans, I mean fully control all your fans simply and creatively. If you want full control of all your fans (Including GPU fans) then this app is King and its free. Step aside outdated 'Speedfan' app, here is your successor. Then try this and see if it makes a difference. What's New Similar to 4 SpeedFan is a hardware monitor software that can access temperature sensors, but its main feature is that it can control fan speeds depending on the capabilities of your. The best fan control app Ive used on Windows 11. I have my desired temp set 3 degrees higher than my normal cpu idle temp. First check the fan power connector to the motherboard, by removing and reconnecting. Win9x:NO 64Bit:YES GiveIO:NO SpeedFan:YES I/O properly initialized Linked ISA BUS at 0290 Scanning ISA BUS at 0290. Rebooting or reinstalling speedfan temporarily fixes the problem, but it occurs again soon. Clicking on "CPU Temp" opens up a selection on the bottom for desired temp and warning temp. I dont think any major changes have occurred recently. In my case I have the cpu temp activating both the cpu and chipset fan to simplify things a bit. Expand the temp sensor item you want to change and check the corresponding fan speed control on the list. 12/7/2023 0 Comments Rar for windows 10 64 bit![]() This will save you disk space, transmission costs AND valuable working time as well. By consistently creating smaller archives, WinRAR is often faster than the competition. WinRAR puts you ahead of the crowd when it comes to compression.WinRAR is a powerful compression tool with many integrated additional functions to help you organize your compressed archives.You can also download PowerArchiver 2019 Professional.īelow are some amazing features you can experience after installation of WinRAR 6 Free Download please keep in mind features may vary and totally depends if your system support them. The special compression algorithm compresses multimedia files, executables and object libraries particularly well. WinRAR automatically recognizes and selects the best compression method. WinRAR supports all popular compression formats (RAR, ZIP, CAB, ARJ, LZH, ACE, TAR, GZip, UUE, ISO, BZIP2, Z and 7-Zip). This will save you disc space, transmission costs AND valuable working time as well. ![]() WinRAR is a powerful compression tool with many integrated additional functions to help you organize your compressed archives. ![]() ![]() It can be helpful when unpacking a non-solid archive containing files encrypted with different passwords.WinRAR 6 Free Download includes all the necessary files to run perfectly on your system, uploaded program contains all latest and updated files, it is full offline or standalone version of WinRAR 6 for compatible versions of Windows, download link at the end of the post. Name of unpacking file is now included into WinRAR incorrect password warning for RAR5 archives. When using "File/Change drive" command, WinRAR saves the last folder of previous drive and restores it if that drive is selected again later.ħ. Previous versions ignored -ri and set the priority to low in the presence of -ibck switch.Ħ. If -ibck -ri switches are used together, WinRAR process sets the priority specified in -ri switch. It can be useful if only the archive type or total information is needed.ĥ. Switch -idn hides archived names also in 'v' and 'l' commands. In the past this extended error information was available in WinRAR, but not in SFX archives.Ĥ. Now this message is followed by a detailed reason like access denied or file being used by another process. Where appropriate, SFX archive displays the additional line with detailed error information provided by operating system.įor example, previously such archive would display "Cannot create file" message alone. We would like to express our gratitude to Igor Sak-Sakovskiy for bringing this issue to our attention.ģ. In limiting the practical application of this attack. Such attack is only possible if the intruder has managed to spoof or otherwise control user's DNS records. This is done to prevent a malicious web page from executing existing files on a user's computer. It also implements additional checks within the web notifier. WinRAR uses https instead of http in the web notifier window, home page and themes links. We are thankful to Jacob Thompson - Mandiant Advantage Labs for reporting this issue.Ģ. We already prohibited extracting contents of such malformed archives in WinRAR 6.01. It is done to prevent possible attacks with inclusion of ZIP archive into the signature body. ZIP SFX module refuses to process SFX commands stored in archive comment if such comment is resided after beginning of Authenticode digital signature. 12/7/2023 0 Comments Concrete flume diffuser![]() The issue is, a manmade swale on your property was put there for a reason, and natural swales are serving a necessary water-carrying service as well, or it would not have naturally formed. Some homeowners consider swales unsightly and would rather have a nice, level lawn or a smooth surface along their driveway. ![]() Traditional Landscape by Encinitas Landscape Architects & Landscape Designers The Design Build Company Can I Fill in a Swale to Make It Level with My Lawn or Other Landscaping? And even though we do not get as much rain as folks who use swales as part of their irrigation system in wetter climates, we can still maximize our use of the rainfall we do receive by strategically including swales in our landscape design. While it might seem like our drought-prone state would not need much in the way of excess water management, drainage swales are a critical part of flood prevention and help keep our ground water cleaner. The primary purpose of most swales in dry climates is to protect structures and to slow down or divert water. More commonly referred to by laypeople as ditches or gutters, swales are often found along sloping driveways, adjacent to roads and parking areas, incorporated into golf courses, winding along the contours of hills on farms and in backyards, or along curbs to guide water away from roadways and into storm drains. Locally, swales can be used for this purpose, but they are more often an integral part of the drainage plan for residential, commercial and municipal properties. They are a popular choice among eco-minded homeowners in these areas who use them to direct water to flower or vegetable gardens, to limit runoff, and to trap silt and pollutants in surface runoff. ![]() In areas that receive more annual rainfall than we do here in sunny Southern California, swales are considered a more efficient way to capture rainwater than rain barrels. They rely on gravity to move water and are designed to direct the water where we want it to go. Depending on their function, they may run along the contour lines of a hillside and may have a berm on the downhill side of the ditch. In simple terms, they are generally shallow ditches that have gently sloping sides. Swales can be part of an area’s natural landscaping, or they can be created to help ensure proper drainage, minimize runoff or capture storm water. Guide water away from homes and roadways.Let’s start with the dictionary definition of swale, which is - according to Merriam-Webster - “a low-lying or depressed and often wet stretch of land.” Swale Uses What is a Drainage Swale? Can I Fill a Swale to Level it Out? Can I Dig a Swale? What to Avoid When Landscaping Drainage Swales How To Landscape Drainage Swales What is a Drainage Swale? Contemporary Landscape by Carmel Landscape Contractors Woolly Blue Landscaping Table of Contents ![]() Honey Mustard Sauce: To make the sauce extra spicy add about 1 teaspoon cayenne pepper.Do not sear the chops for a long time, they'll turn dry and chewy. It'll also boost the flavors of the dish. This will help lock the moisture and keep the chops tender & juicy. Sear pork chops: Sear the pork chops briefly until golden to prevent them form drying. ![]() Honey Mustard Pork Chops and potatoes Best Tips
12/7/2023 0 Comments My milly walkthrough![]() However, modified versions of apps and games for both Android and iOS devices are sometimes distributed through other means, such as jailbreaking or sideloading. Q: Can I use a MOD APK on both Android and iOS devices? A: No, MOD APKs are only available for Android devices, while iOS Hacks are only available for iOS devices. ![]() Finally, you can install the MOD APK by opening the downloaded file and following the on-screen instructions. Then, you will need to enable the "Unknown sources" option in your Android/iOS device's settings to allow installation of apps from outside the Google Play Store/App Store. ![]() Q: How to install a MOD APK? A: To install a MOD APK, you will need to first download it from our link above. However, some argue that modifying an app or game for personal use or to improve its functionality is legal under fair use principles. In general, modifying an app or game in this way is a violation of the app or game's terms of service. Q: Is a MOD APK Legal? A: The legality is a matter of debate. These modifications can include changes to gameplay mechanics, added features, or unlocked content that is otherwise only available through in-app purchases or other means.
12/6/2023 0 Comments Mumble rap song![]() ![]() r/Music does not operate a discord server.r/Music is functioning normally, although some services are still being migrated.August, 2023: r/Music is back open for business!.“And I’ll continue to listen because of the beats.Looking for music by smaller artists? Check out /r/listentothis Community Guidelines & Rules Are you a musician? Read our guide to promoting your music. “I think the genre is going to continue to grow,” Rafati said. Nevertheless, as the face of rap continues to evolve, the artists and songs on the forefront of the change will undoubtedly receive criticism as well as support. ![]() “Old-school songs have better lyrics mumble rap has better beats.” “I don’t really care about the lyrics because they are all essentially the same,” Rafati said. Senior Sahm Rafati said that the beats of his favorite artists including Nav, Famous Dex and Ski Mask “are hype.” “They're doing what they enjoy and other people like me enjoy it so I don't see the reason or need to hate on them,” Pai said. However, he also said that mumble rappers do not deserve all the criticism they get. Pai agrees with some of mumble rap’s critics as he believes the rappers themselves do not deserve as much fame as, say, the producers who make the beats and do most of the behind-the-scenes work to make the song what it is. Some of his favorite songs are “Lifestyle” by Rich Gang, “March Madness” by Future and “Lemonade” by Gucci Mane. “I like mumble rap because the beat and tune are addicting and easy to enjoy,” he said. Sophomore Ronak Pai is one such student who began listening to mumble rap after his sister showed him the song “Trap Queen” by Fetty Wap. Like most forms of artistical expression, rap has found a way to permeate the lives of students all around the country, including many Saratoga students who follow the trend. “They don't know how to categorize it, 'cause it's art. "They don't understand my slang or my accent,” 21 Savage said. In a 2017 interview with the Rolling Stones, 21 Savage said that he felt not everyone who is called a mumble rapper actually mumbles in their music. With all the heat they take from critics, mumble rappers have responded by defending their music. Out of 246,000 reactions to the video, 100,000 are dislikes.īecause the rap genre has been saturated with many wannabe rappers such as Mongeau and Team 10, these artists, who do not have much talent, have resorted to mumble rap. YouTube mogul Tana Mongeau recently released a music video for her first rap song, “Hefner,” in November, and the video has since garnered over 5 million views. Nonetheless, many YouTubers and celebrities have jumped on the mumble rap wave. Mumble rap’s takeover of hip hop, to Eminem, undermines the importance of lyricism. In one 2017 episode of his co-hosted podcast, record producer Rick Rubin said that for Eminem, mumble rap “is a little bit of a culture shock because there’s a new wave of hip-hop that’s not really what he’s about.”įor Eminem, the rhythm and lyrics need to “bounce off of the beat” in a certain way, Rubin said. In fact, even old-school rappers such as Eminem have publicly denounced this new wave of rappers. “Mumble rap” was first coined by rapper Wiz Khalifa while referencing rappers Lil Uzi Vert and Lil Yachty in a 2016 interview with Hot 97 host Ebro Darden, and the term has come to define more than just a subgenre of hip hop now, it is used regularly as a way to express disapproval about up-and-coming rappers who do not focus as much on their lyrics. The majority of these rappers are relatively new to the rap game, emerging in the past few years and quickly moving to the forefront of rap. Other popular mumble rappers include Desiigner, Lil Uzi Vert, 21 Savage, Future, Playboi Carti, Lil Yachty and the trio Migos. The lyrics are more slurred and sung to harmonize with the melody lyricism itself takes a backseat in mumble rap songs, with the “vibe” that the songs make listeners feel taking priority. ![]() Mumble rap mainly differs from more classic rap because of its reliance on hard beats and heavy bass rather than lyricism to create a more catchy and energetic feel, making it popular at parties and clubs. Mumble rap’s popularity increased dramatically in 2016 and continued into 2017. Lil Pump is one of many artists of the new “mumble rap” generation sweeping the hip hop genre - a generation whose lack of lyricism and often indecipherable pronunciation have prompted critics ranging from old-school rappers and modern listeners to label the trend as inauthentic rap. The words “Gucci Gang” are repeated 53 times in the song. That’s really all rapper Lil Pump says in his recent hit song. “Gucci gang, Gucci gang, Gucci gang, Gucci gang, Gucci gang, Gucci gang, Gucci gang.” 12/6/2023 0 Comments Amazon kindle online reader![]() Now, the web-based Kindle app is available globally, including users of localized Kindle Stores (UK, Germany, France, or India, to name the few). At that time it was available only for Kindle users registered in . Kindle Cloud Reader was launched in August 2011. ![]() It’s available for Kindle users around the world Note: make sure to log out from your Amazon account before leaving the public computer. Under the Cloud tab you’ll see all books you bought in the Kindle Store. Any computer in a public space, like a library or internet café, is enough to access the books stored in your Kindle cloud.įind the computer, open the browser, and go to url address. In fact, you don’t need to own any device at all. You don’t need to have any of your devices with you, to access your Kindle books. your computer with a Kindle app installed.your mobile device with a Kindle app installed,.If someone says “access your books from any device”, they assume you understand it as “any device you own”: Access your Kindle books from any computer with a web browser So, in fact, it’s a webpage with a special interface that lets read books on a computer. It’s a way to access your Kindle cloud library via the web browser. It’s not the Kindle e-reader, not Amazon Cloud Drive, and not your Kindle cloud library. The Kindle cloud is everything under Manage Your Content and Devices (formerly Manage Your Kindle) section in your Amazon account settings page. This remote archive is called the “cloud”, and you can access it from any Kindle device or app, and obviously Kindle Cloud Reader. Kindle cloud libraryĪll the books added to Kindle account are stored on Amazon servers, not on the particular device. You can use it to store pictures and personal documents, to make them available from any device by simply signing in to your Amazon Cloud Drive account. It has nothing to do with your Kindle books. It’s a cloud storage service offered by Amazon, similar to Google Drive or Dropbox. ![]() Let’s take a closer look at each one: Amazon Cloud Drive Many users confuse Kindle Cloud Reader with other services and features offered by Amazon. Kindle Cloud Reader has the interface similar to dedicated Kindle apps. You’ll see here a list of books you bought on Amazon, and be able to read them.īefore we move on to the details, there is one thing to be clarified. You don’t even need to own a smartphone with a screen large enough to let you comfortably read. You don’t have to spend money on Kindle e-reader or Amazon Fire tablet. Kindle Cloud Reader is a free, web-based app that you can visit by going to the url address. 12 best metal accessories and home decor for book lovers Sep 4, 2023 12/6/2023 0 Comments Anki web decksOverall, the goal of this guide is to make you a decent Anki user in the fastest way possible. Redditors seem to agree: The very first version of this article was read by thousands of people from Reddit - awesome guys out there. You want a guide that’s Lean, rather than filled with information you can’t readily use. The Anki manual is helpful, but it’s an app documentation rather than a quick-start guide. You only need to get better at using the ESSENTIAL controls to be able to start driving it. You don’t start driving a car by studying the ENTIRE manual. It’s much like learning how to drive a car: Now, this guide exists because I believe you just need to learn the few core info if you’re just looking to start. Study anywhere! Studying felt less effortful than ever the moment I started using Anki before.Remember almost anything you want without having to re-read. ![]()
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